Matrix metalloproteinases involvement in pathologic conditions Cornelia Amalinei, Irina-Draga Caruntu, Simona Eliza Giusca, Raluca Anca Balan Matrix metalloproteinases MMPs have a great variability that provides a complex intervention in pathophysiological conditions.
MMPs roles in pathology may be grouped into the following main types: 1 tissue destruction, as in cancer invasion and metastasis, rheumatoid arthritis, osteoarthritis, different types of ulcers, periodontal disease, brain injury and neuroinflammatory diseases; 2 fibrosis, as in liver cirrhosis, fibrotic lung disease, otosclerosis, atherosclerosis, and multiple sclerosis; 3 weakening of matrix, as in dilated cardiomyopathy, epidermolysis bullosa, aortic aneurysm and restenotic lesions.
Recent data also adds new MMPs functions in angiogenesis and apoptosis.
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Interesting opposite intervention in escaping mechanisms vs. As MMP-7 is expressed by tumor cells of epithelial and mesenchymal origin, it may be used as a biological marker of an aggressive phenotype and viermele eunice a target of therapeutic intervention.
Prostate cancer proteomics: Current trends and future perspectives for biomarker discovery
MMPs play a pivotal role in the pathogenesis of arthritis, atherosclerosis, pulmonary emphysema, and endometriosis. Although MMP involvement in pathology is more than simple excessive matrix degradation, or an imbalance between them and their specific tissular inhibitors TIMPsMMP inhibition may be of therapeutic benefit, so synthetic MMPs inhibitors had been developed and are currently under clinical testing.
Diagnostic and clinical significance of D expression in the normal human thymus and thymoma M.
In the past 4 years, researchers have realized real-time, sensitive, and specific tests of selected cancer markers, using a range of advanced techniques, including CE-ECL, SPR, LIF, spectrum techniques, protein chips, and genetic chips. Based on the said accomplishments, they developed an improved CE-ECL process to detect prolidase, a marker for both liver and breast cancers.
Raica, Cancer genetic markers. Kondylis, L. Mogoanta, Svetlana Encica, Anca Maria Cimpean Human thymus development and thymoma behavior remain elusive, in spite of many acquisitions in the field in last decades.
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In the present paper, we analyzed the immunohistochemical expression of D in the normal human thymus and thymoma. In both fetal cancer genetic markers postnatal normal thymus, we found a strong expression of D in the subcapsular and cortico-medullary epithelial cells, and lack of expression in the thymus of involution. These findings support a role for podoplanin in the proliferation of some subtypes of epithelial cells of the normal thymus stroma.
In thymoma, the expression of D was detected in neoplastic cells in 18 cancer genetic markers 26 cases No correlation was found between D expression and histological types of thymoma, but strong correlation was noticed with tumor stage. Based on these results, it is suggested that D expression is a good predictor of invasion and can be considered as a potential target for therapy in selected cases.
Cretoiu, D. Cretoiu, R. Usvat, L.
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Both host and viral factors contribute to the development of steatosis in chronic hepatitis C. Steatosis cancer genetic markers an initial stage, which promotes hepatic fibrosis through oxidative stress. Aim: To assess the pathogenic mechanism of genotype 1 hepatitis C virus in steatosis and to evaluate the correlation between the degree of steatosis and the level of oxidative stress.
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Patients and Methods: The study cancer genetic markers carried out on 50 patients 29 males, 21 females with genotype 1 HCV and liver biopsy proven chronic hepatitis C. Patients with other etiology of chronic liver disease were excluded.
We statistically correlated the degree of steatosis with clinical age, sex, waist circumferences and biological parameters alaninaminotransferase, gammaglutamyltranspeptidase - GGT, insulin, ferritin, serum viral load, oxidative stress.
No relationship was found between steatosis and viral replication. Conclusions: The pathogenic mechanism of genotype 1 HCV in steatosis is independent from viral replication and it may be linked to virus induced metabolic abnormalities such as IR.
CNS Cancer; Models, Markers, Prognostic Factors, Targets, and Therapeutic Approaches
Increased levels of free radicals, correlated with moderate and severe steatosis suggest the intervention of oxidative stress in determining the hepatic lesions associated with steatosis. Intratemporal course of the facial nerve: morphological, topographic and morphometric features Nicoleta Maru, A.
Cheita, Carmen Aurelia Mogoanta, B. Prejoianu The purpose of this study is to present some morphological and morphometric aspects of the facial nerve and especially of the tympanic and mastoid segments of this nerve. The authors follow up a mesoscopic study concerning the tract length, angulation, width of these segments and the anatomic relations with the important structures of the middle ear. At the same time, some anatomical variations which involve the canal of the facial nerve dehiscences, tract deviation or other anatomical deviations are presented.
Van Meir Cancers of the central nervous system are among the most lethal of human neoplasms. They are recalcitrant to even intensive multimodality therapies that include surgery, radiotherapy and chemotherapy. Moreover, especially in children, the consequences of these therapies can itself be devastating and involve serious cognitive and developmental disorders.
To evaluate the risk of the facial nerve injury during operations for chronic otitis media with or without cholesteatoma, stapedectomy in otosclerosis, exploratory tympanotomy, tympanoplasty, canaloplasty, osteomas surgery or other otologic surgery that involve facial nerve area. The intricate course of the facial nerve through the temporal bone is of cancer genetic markers concern to all otologic surgeons, since it often traverses the surgical field.
Therefore, authors will cancer genetic markers the course of the facial canal through the petrosal portion of the temporal bone from the internal auditory meatus to the stylomastoid foramen, paying particular attention to its relations to adjacent structures.
The immunohistochemical expression of the pprotein in gastric carcinomas. Correlation with clinicopathological factors and survival of patients Daniela Lazar, Sorina Taban, I. Goldis, Iulia Ratiu, C.
Vernic Background: Ptumor suppressor gene has an essential role in controlling cell cycle and initiating carcinogenesis.