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MALIGNANT TUMORS OF DIGESTIVE ORGANS AND LIVER METASTASES AT THE TIME OF DIAGNOSIS

Imaging of metastatic liver disease

Source: Clujul Medical. Jun, Vol.

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Abstract: Neoadjuvant image-guided therapies comprises all locoregional treatment administred to hepatocellular caricinoma patients in order to maintain eligibility during liver transplantation waiting time: transcatheter arterial chemoembolization TACEselective internal radiation therapy SIRTchemical alcohol injection CAIradio frequency ablation RFA. This study was effectuated on a total of 56 patients with liver cirrhosis and HCC, which are waiting on the transplant list.

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According to imaging appearance, compared with imaging study before treatment, the results were interpreted as such: tumor regression, identical size and tumor progression. The treated HCC nodules were analyzed by pathology at the time of liver transplantation. The follow up was made clinically, biologically alpha-fetoprotein AFP level, and imaging at one month after treatment and every 3 months after transplantation.

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The average time between treatments up the transplantation was Residual tumor or tumor progression at index nodule level was proven in 14 patients; 8 patients had new lesions. On pretransplant imaging followup 38 of 68 nodules were stable or in regression. Contrast imaging exams have a tendency of underestimating viable tumor fraction of the treated lesions and can omit new tumor sites.

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Neoadjuvant therapy are palliative unable to provide a hepatic cancer ct for HCC. They are useful by improving outcomes and represents a bridge to liver transplantation.

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